{"id":2889,"date":"2024-03-08T14:46:24","date_gmt":"2024-03-08T14:46:24","guid":{"rendered":"https:\/\/vingioklinika.lt\/?post_type=istyrimo-programos&#038;p=2889"},"modified":"2024-11-28T17:49:10","modified_gmt":"2024-11-28T17:49:10","slug":"celiakijos-istyrimo-programa","status":"publish","type":"istyrimo-programos","link":"https:\/\/vingioklinika.lt\/en\/istyrimo-programos\/celiakijos-istyrimo-programa\/","title":{"rendered":"Celiakijos I\u0161tyrimo programa"},"content":{"rendered":"<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"cms-elementor-section-corner cms-elementor-section-corner-bottom\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"cms-overlay-gradient\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"cms-elementor-section-corner cms-elementor-section-corner-bottom\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"cms-elementor-section-corner cms-elementor-section-corner-bottom\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<div class=\"et_pb_row et_pb_row_0 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p>Celiakija \u2013 tai liga, kuri pasirei\u0161kia plonojo \u017earnyno nepakantumu jav\u0173 kult\u016br\u0173 baltymams, vadinamiems gliutenu.<\/p>\n<p>\u0160iandien jau \u017einoma, kad celiakija yra paveldima liga, ja serga genetin\u012f polink\u012f turintys asmenys. Moksli\u0161kai celiakija apib\u016bdinama kaip sistemin\u0117 autoimunin\u0117 liga, sukelianti \u017earn\u0173, odos, kepen\u0173, s\u0105nari\u0173 ir kit\u0173 organ\u0173 pa\u017eeidimus.<\/p>\n<p>Nors celiakijos liga gali pa\u017eeisti daugel\u012f organ\u0173 ir sistem\u0173, visgi da\u017eniausiai ji pa\u017eeid\u017eia vir\u0161kinam\u0105j\u012f trakt\u0105 ir sukelia:<\/p>\n<ul>\n<li>viduriavim\u0105 arba viduri\u0173 u\u017ekiet\u0117jim\u0105;<\/li>\n<li>pilvo p\u016btim\u0105;<\/li>\n<li>v\u0117mim\u0105;<\/li>\n<li>svorio netekim\u0105.<\/li>\n<\/ul>\n<p>Kai kurie asmenys skund\u017eiasi ne tik vir\u0161kinamojo trakto sutrikimais, bet ir<\/p>\n<ul>\n<li>nuolatiniu nuovargiu;<\/li>\n<li>kaul\u0173 skausmu;<\/li>\n<li>opel\u0117mis burnoje;<\/li>\n<li>depresija ir kitomis psichologin\u0117mis problemomis.<\/li>\n<\/ul>\n<p>Vienintelis celiakijos gydymas yra grie\u017eta begliutenin\u0117 dieta. Tai rei\u0161kia, kad reikia visi\u0161kai nevartoti kvie\u010di\u0173, mie\u017ei\u0173, rugi\u0173 ir avi\u017e\u0173 ir j\u0173 produkt\u0173.<\/p>\n<p>Kaip ir daugeliui lig\u0173, labai svarbu laiku nustatyti celiakijos diagnoz\u0119, tuomet labai greitai galima pasveikti ir jaustis puikiai. Kuo anks\u010diau yra pa\u0161alinamas gliutenas i\u0161 vartojam\u0173 maisto produkt\u0173, tuo ma\u017eiau sveikatos sutrikim\u0173 jis sukels.<\/p>\n<p>Celiakijos atveju labai svarbus kompleksinis asmen\u0173 i\u0161tyrimas \u2013 kraujyje gali b\u016bti randami tiek vienos r\u016b\u0161ies, tiek keli\u0173 r\u016b\u0161i\u0173 antik\u016bnai. Galutinei celiakijos diagnozei teigiami antik\u016bn\u0173 tyrimai patvirtinami dvylikapir\u0161t\u0117s \u017earnos audini\u0173 biopsija.<\/p>\n<p>Tyrimai, rekomenduotini celiakijos i\u0161tyrimui:<\/p>\n<p><strong>Bendras imunoglobulinas A (IgA).<\/strong>\u00a0<strong>Imunoglobulinas A \u2013 tai<\/strong>\u00a0imunin\u0117s sistemos sudedamoji dalis. Sergant celiakija net kelis kartus suma\u017e\u0117ja imunoglobulino A (IgA) kiekiai.<\/p>\n<ul>\n<li>Imunoglobulinas A (IgA)<\/li>\n<\/ul>\n<p>Vieni specifi\u0161kiausi\u0173 celiakijos ligai kraujo tyrim\u0173 yra antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119 (anti-tTG). Audini\u0173 transgliutaminaz\u0117 \u2013 tai fermentas, kuris padeda atstatyti pa\u017eeistus audinius. Sergantiesiems celiakija, vartojant gliuteno turin\u010dius maisto produktus, susiformuoja \u0161io fermento antik\u016bnai. Tuomet fermentas sunaikinamas ir \u012fvyksta tolimesnis organ\u0173 ir audini\u0173 pa\u017eeidimas, atsiranda celiakijos ligos po\u017eymiai. Da\u017eniausiai organizme gaminami IgA klas\u0117s antik\u016bnai, ta\u010diau daliai asmen\u0173 (apie 2-3 proc.) yra imunoglobulin\u0173 A klas\u0117s (IgA) nepakankamumas, tod\u0117l \u0161iems asmenims antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119 IgA gali b\u016bti neigiami. Tokiu atveju rekomenduojama atlikti antik\u016bn\u0173 prie\u0161 audini\u0173 transgliutaminaz\u0119 IgG tyrim\u0105. Antik\u016bn\u0173 prie\u0161 audini\u0173 transgliutaminaz\u0119 (anti-tTG ) tyrimai labai naudingi ir tuo, kad j\u0173 kiekis parodo ne tik celiakijos diagnoz\u0119, bet ir ligos sunkum\u0105, t.y. kuo didesnis antik\u016bn\u0173 kiekis, tuo tik\u0117tinas didesnis, sunkesnis pa\u017eeidimas. Antik\u016bn\u0173 prie\u0161 audini\u0173 transgliutaminaz\u0119 (anti-tTG) tyrimai da\u017enai gali b\u016bti neigiami vaikams iki 3 met\u0173, tod\u0117l jiems rekomenduojama atlikti kitus diagnostinius tyrimus.<\/p>\n<p>Jeigu laikomasi grie\u017etos begliutenin\u0117s dietos, antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119\u00a0 i\u0161 l\u0117to pradeda ma\u017e\u0117ti. Normalus \u0161i\u0173 antik\u016bn\u0173 kiekis gali b\u016bti po 6\u201312 m\u0117n. nuo dietos prad\u017eios. Tuomet klinikiniai simptomai nyksta, ma\u017e\u0117ja \u017earnyno pa\u017eeidimas.<\/p>\n<ul>\n<li>Antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119 (anti-tTG IgG)<\/li>\n<li>Antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119 (anti-tTG IgA)<\/li>\n<\/ul>\n<p>Daliai asmen\u0173 antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119 nesusiformuoja arba j\u0173 kiekiai yra nedideli. \u0160iems asmenims, esant ai\u0161ki\u0173 celiakijos po\u017eymi\u0173\/simptom\u0173, rekomenduojama atlikti kitus imunin\u0117s sistemos atsako antik\u016bnus \u2013 antik\u016bnus prie\u0161 deaminintus gliadino baltymo epitopus IgA klas\u0117s bei IgG klas\u0117s. \u017darnyno l\u0105stel\u0117se skaidant baltym\u0105 gliadin\u0105, susiformuoja modifikuoto gliadino fragmentai, prie\u0161 kuriuos ir pradedami gaminti antik\u016bnai. Daugiausia ir pirmiausia gaminami antik\u016bnai imunoglobulin\u0173 A klas\u0117s (IgA), ta\u010diau d\u0117l bendro IgA tr\u016bkumo kai kuriems asmenims \u0161ios klas\u0117s antik\u016bnai gali b\u016bti negaminami. Tod\u0117l rekomenduotina i\u0161tirti ir imunoglobulin\u0173 G klas\u0117s (IgG) antik\u016bnus.<\/p>\n<p>Antik\u016bn\u0173 prie\u0161 deaminintus gliadino baltymo epitopus tyrimai ypa\u010d svarb\u016bs celiakijos ligos monitoringui (sekimui) laikantis beglitimin\u0117s dietos.<\/p>\n<ul>\n<li>Antik\u016bnai prie\u0161 deaminintus gliadino baltymo epitopus IgA (anti-DGP IgA)<\/li>\n<li>Antik\u016bnai prie\u0161 deaminintus gliadino baltymo epitopus IgG (anti-DGP IgG)<\/li>\n<\/ul>\n<p>Celiakijos diagnostikai svarb\u016bs yra ir emdomisiumo antik\u016bn\u0173 nustatymas. Endomisiumas \u2013 tai plonas jungiamojo audinio sluoksnis, kuris dengia \u017earnyno raumenines skaidulas. Antik\u016bnai prie\u0161 endomisium\u0105 susiformuoja, kai dirginama \u017earnyno gleivin\u0117, tod\u0117l sergantiems aktyvia celiakijos forma asmenims \u0161ie antik\u016bnai aptinkami kone visiems. Tad \u0161is tyrimas atliekamas esant ry\u0161kiems celiakijos simptomams, vaikams bei\u00a0 norint i\u0161vengti plonojo \u017earnyno biopsijos. Kaip ir kiti antik\u016bnai, sergant celiakija, taip ir antik\u016bnai prie\u0161 endomisium\u0105 ma\u017e\u0117ja, kai laikomasi grie\u017etos begliutenin\u0117s dietos.<\/p>\n<ul>\n<li>Endomisiumo antik\u016bn\u0173 IgG (EMA-IgG) tyrimas<\/li>\n<\/ul>\n<p>Pagal oficialias Celiakijos diagnostikos rekomendacijas antik\u016bnus rekomenduojama tirti tik vartojant gliuten\u0105 ne ma\u017eiau kaip 6 savaites. Nevartojant gliuteno antik\u016bn\u0173 titrai drasti\u0161kai ma\u017e\u0117ja, tad laboratoriniais tyrimais j\u0173 neaptinkama. Ir nors kraujo tyrimai ypa\u010d jautr\u016bs ir specifiniai celiakijos ligai, ta\u010diau esant tam tikroms situacijoms, j\u0173 kiekiai gali b\u016bti nepakankami ligai nustatyti (pvz. pagyvenusiems asmenims, vaikams iki 3 m., vartojant imunin\u0119 sistem\u0105 slopinan\u010dius, moduliuojan\u010dius vaistus ir kt.). Kad b\u016bt\u0173 galima patvirtinti celiakijos diagnoz\u0119, labai svarbus kompleksinis i\u0161tyrimas. Celiakijos antik\u016bn\u0173 tyrimai i\u0161 kraujo padeda atrinkti pacientus, kuriems tikslinga atlikti plonosios \u017earnos biopsijos tyrim\u0105.<\/p>\n<p>Kadangi celiakijos liga yra geneti\u0161kai paveldima, jos diagnostikai svarb\u016bs ir specifiniai ligai genetiniai tyrimai. Genetiniai tyrimai padeda nustatyti diagnoz\u0119 bei \u012fvertinti rizik\u0105 susirgti celiakija ateityje. Apie 90-95 proc. celiakija sergan\u010di\u0173 \u017emoni\u0173 turi specifinius \u017emogaus leukocit\u0173 antigen\u0173 haplotipus DQ2 ir\/arba DQ8. Nusta\u010dius \u0161iuos \u017dLA haplotipus, patvirtinama celiakijos diagnoz\u0117. Ta\u010diau neigiamas \u017dLA haplotip\u0173 DQ2\/DQ8 rezultatas nepaneigia celiakijos diagnoz\u0117s, nes lig\u0105 gali nulemti ir kiti genai.<\/p>\n<p>Genetiniai \u017dLA DQ2\/DQ8 tyrimai skiriami asmenims, kuriems kit\u0173 tyrim\u0173 rezultatai neai\u0161k\u016bs, neatitinka antik\u016bn\u0173 ir biopsijos tyrim\u0173 rezultatai, besilaikantiems grie\u017etos begliutinin\u0117s dietos. Taip pat jie gali b\u016bt skiriami i\u0161tirti artimus giminai\u010dius (brolius, seseris), siekiant \u012fvertinti rizik\u0105 susirgti celiakija.<\/p>\n<ul>\n<li>\u017dLA haptotip\u0173 DQ2\/DQ8\/DR4 d\u0117l celiakijos nustatymas (PGR)<\/li>\n<\/ul>\n<p><strong>Tyrimai:<\/strong><\/p>\n<ol>\n<li>Imunoglobulinas A (IgA)<\/li>\n<li>Antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119 (anti-tTG IgG)<\/li>\n<li>Antik\u016bnai prie\u0161 audini\u0173 transgliutaminaz\u0119 (anti-tTG IgA)<\/li>\n<li>Antik\u016bnai prie\u0161 deaminintus gliadino baltymo epitopus IgA (anti-DGP IgA)<\/li>\n<li>Antik\u016bnai prie\u0161 deaminintus gliadino baltymo epitopus IgG (anti-DGP IgG)<\/li>\n<li>Endomisiumo antik\u016bn\u0173 IgG (EMA-IgG) tyrimas<\/li>\n<li>\u017dLA haptotip\u0173 DQ2\/DQ8\/DR4 d\u0117l celiakijos nustatymas (PGR)<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"et_pb_row et_pb_row_1 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_1 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p><b><strong>Turite papildom\u0173 klausim\u0173? Skambinkite <a href=\"tel:+370 692 38498\">+370 692 38498<\/a>\u00a0(Kauno g. 22, Vilnius) arba ra\u0161ykite\u00a0<a href=\"mailto:info@vingioklinika.lt\">info@vingioklinika.lt<\/a><\/strong><\/b><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"et_pb_row et_pb_row_1 et_pb_gutters3\">\n<div class=\"et_pb_column et_pb_column_4_4 et_pb_column_1 et_pb_css_mix_blend_mode_passthrough et-last-child\">\n<div class=\"et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"featured_media":0,"parent":0,"menu_order":26,"template":"","tyrimu-programos":[101],"class_list":["post-2889","istyrimo-programos","type-istyrimo-programos","status-publish","hentry","tyrimu-programos-bendros-organizmo-istyrimo-programos"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Celiakos tyrimas - Vingio klinika<\/title>\n<meta name=\"description\" content=\"Celiakija \u2013 tai liga, kuri pasirei\u0161kia plonojo \u017earnyno gliuteno netoleravimu. 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